Why the study?
Prior studies deriving eGFR formulas infrequently included high proportions of elderly individuals, African-Americans, and Hispanics.
Does estimated GFR based on cystatin-C improve mortality risk prediction compared to creatinine-based estimated GFR in an elderly, race/ethnically diverse population?
Does estimated GFR based on cystatin-C improve mortality risk prediction compared to creatinine-based estimated GFR in an elderly, race/ethnically diverse population?
In an elderly, multiethnic cohort, estimating GFR using cystatin-C provides superior prediction of all-cause mortality compared to creatinine-based estimates.
May improve mortality risk stratification with cystatin C-based eGFR in elderly diverse adults; observational data leave clinical adoption open pending validation.
Estimated glomerular filtration rate (eGFR) is routinely utilized as a measure of renal function. While creatinine-based eGFR (eGFRcr) is widely used in clinical practice, the use of cystatin-C to estimate GFR (eGFRcys) has demonstrated superior risk prediction in various populations. Prior studies that derived eGFR formulas have infrequently included high proportions of elderly, African-Americans, and Hispanics.
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Willey et al. (2020) studied this question.
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