Why the study?
The study aimed to determine the prevalence of metabolically healthy obesity (MHO), characterize its features compared to metabolically unhealthy obesity (MUHO), and evaluate the effect of weight loss on cardiometabolic risk factors in MHO.
Does weight loss of ≥5% improve cardiometabolic risk factors in patients with metabolically healthy obesity?
Population
389 obese patients aged 18-60
Comparison
MHO vs MUHO, and weight loss of ≥5% body mass after 6 months
Follow-up
6 months
Key result
Metabolically healthy obesity prevalence varied from 9.6% to 38.6% depending on criteria, and a ≥5% body mass decrease over 6 months significantly improved cardiometabolic risk factors (p<0.05).
Authors
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≥5% weight loss was associated with cardiometabolic improvements in metabolically healthy obesity; leaves open optimal definitions and need for randomized confirmation.
Observational (n=389)
Does weight loss of ≥5% improve cardiometabolic risk factors in patients with metabolically healthy obesity?
p-value: p=<0.05
Weight loss in metabolically healthy obesity improves inflammatory and metabolic markers, suggesting that obesity should be treated regardless of metabolic phenotype.
Ostrovskaya et al. (2020) conducted an observational in Obesity (n=389). Weight loss (≥5% body mass decrease) vs. Baseline / MUHO was evaluated on Prevalence of MHO and changes in cardiometabolic risk factors (p=<0.05). Metabolically healthy obesity prevalence varied from 9.6% to 38.6% depending on criteria, and a ≥5% body mass decrease over 6 months significantly improved cardiometabolic risk factors (p<0.05).