Key result
Waist-to-hip ratio was initially associated with incident CVD in women (HR 2.22) and men (HR 1.73), but was no longer significant (P>0.41) after adjusting for traditional risk factors.
Why the study?
Which clinical measure of overweight and obesity is the strongest independent predictor of cardiovascular disease in adults without major CVD at baseline?
Population
2493 Danish men and women, age 41-72 years, without major CVD at baseline
Comparison
Measures of overweight and obesity vs Lowest quartile of overweight/obesity measures
Design
Cohort
Follow-up
median 12.6 years
Authors
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Traditional risk factors fully account for WHR-CVD links; leaves open any incremental value of WHR beyond them.
Cohort (n=2,493)
Which clinical measure of overweight and obesity is the strongest independent predictor of cardiovascular disease in adults without major CVD at baseline?
Effect estimate: HR 2.22 (women) / HR 1.73 (men) (95% CI 1.31-3.77 (women) / 1.12-2.66 (men))
p-value: p=0.0032 (women) / 0.014 (men)
Waist-to-hip ratio is the strongest obesity-related predictor of incident CVD, but its effect is entirely mediated by traditional metabolic risk factors.
Sehested et al. (2010) conducted a cohort in Cardiovascular disease (n=2,493). Waist-to-hip ratio (WHR) vs. Lowest quartile was evaluated on Combined CV event (CV death, nonfatal ischemic heart disease, and nonfatal stroke) (HR 2.22 (women) / HR 1.73 (men), 95% CI 1.31-3.77 (women) / 1.12-2.66 (men), p=0.0032 (women) / 0.014 (men)). Waist-to-hip ratio was initially associated with incident CVD in women (HR 2.22) and men (HR 1.73), but was no longer significant (P>0.41) after adjusting for traditional risk factors.
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