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August 1, 1969Circulation Research42 citationsOpen Access

Myocardial Connective Tissue Metabolism in Response to Injury: HISTOLOGICAL AND CHEMICAL STUDIES OF MUCOPOLYSACCHARIDE AND COLLAGEN IN RAT HEARTS AFTER ISOPROTERENOL-INDUCED INFARCTION

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Population

Arteriosclerotic and nonarteriosclerotic rats (breeder and virgin animals)

Design

Preclinical

Follow-up

up to 7 days

Authors

JJJoseph T. JuddBWBernard C. WexlerGWGeorge Williamson

Discussion

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Overview

Animal data delineate biphasic repair post-MI; leaves open translation to human remodeling or timed interventions.

Structured PICO

P
Population
Arteriosclerotic and nonarteriosclerotic rats (breeder and virgin animals)
I
Intervention
Isoproterenol-induced myocardial infarction
O
Outcome
Histological and chemical changes in connective tissue (mucopolysaccharide, hexosamine, and hydroxyproline) in hearts, livers, and kidneyssurrogate

Isoproterenol-induced myocardial infarction in rats leads to a biphasic connective tissue response characterized by early hexosamine accumulation and later collagen deposition during scar formation.

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Cite This Study

Judd et al. (1969) studied this question.

synapsesocial.com/papers/6a227a9152bd8c5fb191231dhttps://doi.org/10.1161/01.res.25.2.201
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