Why the study?
Does halothane anesthesia compared to pentobarbital anesthesia increase transmural dispersion of repolarization and the development of torsades de pointes in the canine heart in vivo under acquired long QT conditions?
Does halothane anesthesia compared to pentobarbital anesthesia increase transmural dispersion of repolarization and the development of torsades de pointes in the canine heart in vivo under acquired long QT conditions?
Halothane anesthesia, but not pentobarbital, amplifies transmural dispersion of repolarization and promotes Torsades de Pointes under acquired long QT conditions in the canine heart in vivo.
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Halothane may heighten TdP risk with IKr blockade in canine models; leaves open anesthesia effects on human arrhythmia susceptibility.
Weissenburger et al. (2000) studied this question.
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