Key result
Co-incubation of human saphenous vein segments with quinaprilat and the chymase inhibitor SBTI markedly reduced maximum contraction to angiotensin I (12.5 mN) compared to control (30.4 mN).
Population
Human saphenous vein (SV) segments (n=20)
Comparison
Incubation with angiotensin I in the presence of… vs Control (no inhibitor) or single inhibitors
Design
Preclinical
Authors
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Chymase inhibition may potentiate ACE blockade in human veins; leaves open clinical relevance for bypass graft function.
Absolute Event Rate: 12.5% vs 30.4%
Demonstrates the existence of a chymase-dependent alternative pathway for angiotensin II formation in human saphenous veins that remains active during ACE inhibition.
Borland et al. (1998) studied this question. Quinaprilat and soya bean trypsin inhibitor (SBTI) co-incubation vs. Control was evaluated on Maximum contraction in response to angiotensin I. Co-incubation of human saphenous vein segments with quinaprilat and the chymase inhibitor SBTI markedly reduced maximum contraction to angiotensin I (12.5 mN) compared to control (30.4 mN).
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