January 1, 1989Japanese Heart JournalOpen Access

Direct formation of angiotensin II without renin or converting enzyme in the ischemic dog heart.

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Population

Dogs bilaterally nephrectomized 24 hours before ligation of the coronary artery

Design

Preclinical

Authors

MGMasakazu GONDOFukuoka University HMHaruo MARUTAFukuoka University KAKikuo ArakawaGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Hypothesis-generating for kallikrein-mediated local angiotensin II generation in ischemia; does not yet inform human therapy.

Structured PICO

Population

Dogs bilaterally nephrectomized 24 hours before ligation of the coronary artery

Intervention

Acute coronary artery occlusion with administration of aprotinin, captopril, or pepstatin

Outcome

Immunoreactive angiotensin II (IR-Angiotensin II) levels in coronary sinus blood and systemic aortic bloodsurrogate

In the ischemic dog heart, angiotensin II may be generated directly by kallikrein or kallikrein-like proteases, independently of the systemic renin-angiotensin system.

Cite This Study

GONDO et al. (1989) studied this question.

synapsesocial.com/papers/6a7573a05be14952a7f55bed https://doi.org/10.1536/ihj.30.219

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Direct formation of angiotensin II without renin or converting enzyme in the ischemic dog heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Direct formation of angiotensin II without renin or converting enzyme in the ischemic dog heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider