Key result
Flubromazepam (0.1 mg/kg) induced significant place preference in mice, while 100-μM reduced cell viability, increased RR intervals, and inhibited potassium channels in vitro.
Why the study?
Scientific evidence regarding the potential for dependence or other adverse effects of the designer benzodiazepine flubromazepam is currently lacking.
Does flubromazepam induce dependence and cardiotoxicity in preclinical models?
Does flubromazepam induce dependence and cardiotoxicity in preclinical models?
Flubromazepam demonstrates potential for dependence and cardiotoxic effects including increased RR intervals and hERG channel inhibition in preclinical models.
The use of many benzodiazepines is controlled worldwide due to their high likelihood of abuse and potential adverse effects. Flubromazepam-a designer benzodiazepine-is a long-acting gamma-aminobutyric acid subtype A receptor agonist. There is currently a lack of scientific evidence regarding the potential for flubromazepam dependence or other adverse effects. This study aimed to evaluate the dependence potential, and cardiotoxicity via confirmation of the QT and RR intervals which are the factors on the electrical properties of the heart of flubromazepam in rodents. Using a conditioned place preference test, we discovered that mice treated intraperitoneally with flubromazepam (0.1 mg/kg) exhibited a significant preference for the flubromazepam-paired compartment, suggesting a potential for flubromazepam dependence. In addition, we observed several cardiotoxic effects of flubromazepam; 100-μM flubromazepam reduced cell viability, increased RR intervals but not QT intervals in the electrocardiography measurements, and considerably inhibited potassium channels in a human ether-à-go-go-related gene assay. Collectively, these findings suggest that flubromazepam may have adverse effects on psychological and cardiovascular health, laying the foundation for further efforts to list flubromazepam as a controlled substance at both national and international levels.
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Hong et al. (2022) studied this question. Flubromazepam was evaluated on Dependence potential and cardiotoxicity (QT/RR intervals, cell viability, potassium channel inhibition). Flubromazepam (0.1 mg/kg) induced significant place preference in mice, while 100-μM reduced cell viability, increased RR intervals, and inhibited potassium channels in vitro.
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