Key result
A compartmentalized mathematical model of the β1-adrenergic signaling system in mouse ventricular myocytes successfully reproduced experimental data on cAMP dynamics, PKA activation, and L-type Ca2+ current modifications.
A comprehensive mathematical model of the β1-adrenergic signaling system in mouse ventricular myocytes successfully reproduces experimental data and elucidates the complex interactions of ionic currents upon β1-AR activation.
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Supports mechanistic modeling of rodent β1-adrenergic signaling; leaves open human myocyte validation and clinical translation.
Vladimir E. Bondarenko (2014) studied None (Mathematical model of mouse ventricular myocytes). Simulated β1-adrenergic stimulation (Isoproterenol) vs. Simulated basal conditions was evaluated on Model validation against experimental data for cAMP, PKA, and Ca2+ dynamics. A compartmentalized mathematical model of the β1-adrenergic signaling system in mouse ventricular myocytes successfully reproduced experimental data on cAMP dynamics, PKA activation, and L-type Ca2+ current modifications.
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