Key result
Three months of CPAP therapy reversed the significant reduction in baroreflex sensitivity during slow wave sleep observed in OSAS patients compared to healthy controls (p<0.05).
Why the study?
Does 3-month CPAP therapy improve cardiovascular regulation (heart rate/blood pressure variability and baroreflex sensitivity) during different sleep stages in patients with OSAS?
Population
28 patients with obstructive sleep apnea syndrome and 10 age- and sex-matched healthy controls
Comparison
Continuous positive airway pressure therapy for… vs Baseline and healthy controls
Design
Cohort
Follow-up
3 months
Authors
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May restore baroreflex sensitivity during slow-wave sleep in OSAS; hypothesis-generating, requiring RCTs before practice change.
Observational (n=38)
Does 3-month CPAP therapy improve cardiovascular regulation (heart rate/blood pressure variability and baroreflex sensitivity) during different sleep stages in patients with OSAS?
p-value: p=<0.05
CPAP therapy for 3 months restores normal baroreflex sensitivity during slow wave sleep in patients with obstructive sleep apnea syndrome.
Gapelyuk et al. (2011) conducted an observational in Obstructive sleep apnea syndrome (OSAS) (n=38). Continuous positive airway pressure (CPAP) therapy vs. Healthy controls and pre-therapy baseline was evaluated on Baroreflex sensitivity in slow wave sleep (p=<0.05). Three months of CPAP therapy reversed the significant reduction in baroreflex sensitivity during slow wave sleep observed in OSAS patients compared to healthy controls (p<0.05).
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