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March 1, 1987AJP Regulatory Integrative and Comparative Physiology

Control of atrial natriuretic factor release from a rat heart-lung preparation

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Why the study?

Does altering venous return, aortic pressure, or sodium concentration affect ANF release in a rat heart-lung preparation?

Population

Rat heart-lung preparation

Comparison

Altering venous return, increasing aortic… vs Control experiments

Design

Preclinical

Authors

JDJohn R. Dietz

Discussion

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Overview

Hemodynamic stretch stimulates ANF release in rat preparations; extends mechanistic understanding while leaving human translation open.

Structured PICO

Does altering venous return, aortic pressure, or sodium concentration affect ANF release in a rat heart-lung preparation?

P
Population
Rat heart-lung preparation
I
Intervention
Altering venous return (raising reservoir height), increasing aortic pressure, or altering perfusate sodium concentration
C
Comparator
Control experiments (no change in reservoir height, baseline aortic pressure, or different sodium concentrations)
O
Outcome
Changes in perfusate atrial natriuretic factor (ANF) concentration (delta ANF)surrogate

ANF release is stimulated by increased venous return and aortic pressure, but not by changes in plasma sodium concentration, suggesting a role in blood volume and pressure control.

Cite This Study

John R. Dietz (1987) studied this question.

synapsesocial.com/papers/6a228dfdf56da133636d0667https://doi.org/10.1152/ajpregu.1987.252.3.r498
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