Key result
Shortening the atrioventricular interval from 200 ms to 100 ms during DDD pacing significantly improved transmitral E/A wave ratio (from 0.53 to 0.90, P=0.0005) and LV filling time.
Why the study?
Does variation of atrioventricular interval during DDD pacing improve left ventricular diastolic function and reduce ANP and c-GMP levels in patients with complete AV block?
Does variation of atrioventricular interval during DDD pacing improve left ventricular diastolic function and reduce ANP and c-GMP levels in patients with complete AV block?
Absolute Event Rate: 0.9% vs 0.53%
p-value: p=0.0005
Shorter AV intervals (100-150 ms) during DDD pacing improve LV diastolic filling and reduce natriuretic peptide levels compared to longer intervals (200 ms) in patients with complete AV block.
Authors
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Shorter AV intervals may enhance LV filling in paced AV block; leaves open whether this improves outcomes or warrants routine optimization.
Stylıadis et al. (2005) studied Complete AV block and normal systolic function (n=22). Variation of atrioventricular interval vs. 200 ms was evaluated on Transmitral E/A wave ratio (p=0.0005). Shortening the atrioventricular interval from 200 ms to 100 ms during DDD pacing significantly improved transmitral E/A wave ratio (from 0.53 to 0.90, P=0.0005) and LV filling time.
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