Congestive cardiac failure was associated with markedly higher plasma concentrations of cardiodilatin (964 pmol/l) compared to normal subjects (118 pmol/l).
Observational (n=41)
Are plasma concentrations of cardiodilatin elevated in patients with congestive cardiac failure compared to normal subjects?
Cardiodilatin is a circulating cardiac peptide jointly released with atrial natriuretic peptide, and its plasma concentrations are significantly elevated in patients with congestive heart failure.
Absolute Event Rate: 964% vs 118%
Plasma concentrations of cardiodilatin, the peptide sequence at the amino terminal of the pro-atrial natriuretic peptide, in 17 normal subjects ranged from 59 to 202 (mean 118 (SEM) (9] pmol/l. Recumbency increased the mean (SEM) concentration to 160 (13) pmol/l. The plasma concentration of cardiodilatin in 24 patients with congestive cardiac failure was much higher (964 (175) pmol/l) than in the normal subjects. It was highest in those with heart failure in New York Heart Association functional classes III and IV and the concentration correlated both with atrial natriuretic peptide concentrations and left ventricular ejection fraction. Concentrations rose during induced tachycardia in three patients tested. Chromatography showed a single clean peak of plasma cardiodilatin immunoreactivity. It seems that cardiodilatin is a second circulating cardiac peptide that is jointly released with atrial natriuretic peptide by common stimuli. Other workers have reported that, like atrial natriuretic peptide, three partial cardiodilatin sequences can stimulate renal particulate guanylate cyclase and increase cyclic guanosine monophosphate. The simultaneous release of cardiodilatin in higher circulating concentrations than atrial natriuretic peptide may be relevant to the finding that appropriate concentrations of exogenous atrial natiuretic peptide alone do not produce the full renal effects associated with endogenous peptide release.
Meleagros et al. (Fri,) conducted a observational in Congestive cardiac failure (n=41). Congestive cardiac failure vs. Normal subjects was evaluated on Plasma concentration of cardiodilatin. Congestive cardiac failure was associated with markedly higher plasma concentrations of cardiodilatin (964 pmol/l) compared to normal subjects (118 pmol/l).