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“What we showed in CAMERA-MRI II is that these patients who had, we'd say a moderate burden of scar, so the average scar burden was around 11%, which is consistent with other studies that have looked at patients with scar undergoing catheter ablation... what we found is that those patients had a still around a 20% improvement in ejection fraction. Their absolute improvement was not as high as those who had no scar... but the improvement from baseline really kind of mirrored that we've seen in patients without scar.”
“I think what it was telling us is that even though these patients that have scar burdens, the capacity of the ventricle to respond to rhythm control or the impact of AF on their ejection fraction is still quite significant and that these patients still improve substantially with rhythm control with catheter ablation.”
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Segan et al. (2025) studied this question.
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