Key result
In an optimized equivalent electrical circuit model, decreased vessel compliance reduced coronary arterial flow and increased venous flow, while increased resistance diminished arterial flow.
An optimized equivalent electrical circuit model demonstrates that changes in intramyocardial vessel resistance and compliance can explain the squeezing effects of the myocardium on coronary blood flow.
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Model insights into coronary flow remain preclinical; leaves open in vivo validation before any clinical relevance.
By employing an optimized equivalent electrical circuit of the coronary circulation, the authors have examined the effects of time-dependent change in intramyocardial vessel resistance and compliance on coronary blood flow. The cost function involved the squares of perfusion pressures, flow rates, aortic pressure and the active intramyocardial pressures by the active elastance in cardiac muscle. Decrease in vessel compliance reduced coronary arterial flow rate and increased venous flow rate. Increase in resistance diminished arterial flow but enhanced venous flow. These changes can explain squeezing effects in the myocardium. The present model is available for estimating coronary circulation.
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Hirayama et al. (2002) studied coronary circulation. time-dependent change in intramyocardial vessel resistance and compliance was evaluated on coronary blood flow. In an optimized equivalent electrical circuit model, decreased vessel compliance reduced coronary arterial flow and increased venous flow, while increased resistance diminished arterial flow.
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