What does this research mean for the field?

Intramyocardial compliance is the primary mechanism responsible for high zero flow pressures and the characteristics of coronary diastolic pressure-flow relations. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study aims to identify intramyocardial compliance as a key factor in high zero flow pressures and its impact on coronary pressure-flow relations.

March 1, 1985Circulation ResearchOpen Access

Coronary diastolic pressure-flow relation and zero flow pressure explained on the basis of intramyocardial compliance.

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Authors

JSJos A. E. SpaanLeiden University

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Implication

Hypothesis-generating model implicates intramyocardial compliance; leaves open in vivo validation for coronary zero-flow pressures.

Key Points

The study aims to identify intramyocardial compliance as a key factor in high zero flow pressures and its impact on coronary pressure-flow relations.
Estimated compliance distribution within the coronary circulation using data from mesenteric vessels.
Analyzed the effects of smooth muscle tone on arteriolar compliance based on transmural pressure.
Conducted a compartmental analysis to predict intramyocardial compliance relative to epicardial arterial compliance.
Predicted overall intramyocardial compliance may exceed epicardial arterial compliance by a factor of 45.
Observed that coronary pressure at zero flow (Pf) is higher when measured later in diastole.
Discrepancies in pressure-flow relations correlate with variances in pressure, resistance, and compliance distributions.

Cite This Study

Jos A. E. Spaan (1985) studied this question.

synapsesocial.com/papers/6a1c5b9fea84844e355fc8a1 https://doi.org/10.1161/01.res.56.3.293

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Coronary diastolic pressure-flow relation and zero flow pressure explained on the basis of intramyocardial compliance.

Discussion

Member takes

Implication

Key Points

Cite This Study

Coronary diastolic pressure-flow relation and zero flow pressure explained on the basis of intramyocardial compliance.

Discussion

Member takes

Implication

Key Points

Cite This Study

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