Key result
Changes in peripheral resistance and aortic compliance in isolated canine left ventricles demonstrated an inverse linear relationship between pressure and cardiac output when coronary flow was constant.
Why the study?
How do changes in peripheral resistance and aortic compliance affect left ventricular pressure, flow, and pressure-volume loops in isolated canine hearts?
How do changes in peripheral resistance and aortic compliance affect left ventricular pressure, flow, and pressure-volume loops in isolated canine hearts?
Changes in aortic compliance and peripheral resistance predictably alter left ventricular pressure-volume loops and flow waveforms, which can be modeled electrically.
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Should not guide clinical afterload management; leaves open translation of canine ventricular-vascular coupling to human hearts.
Ishide et al. (1985) studied Isolated canine left ventricle preparations. Changes in peripheral resistance and aortic compliance was evaluated on Pressure, flow, and stroke volume responses. Changes in peripheral resistance and aortic compliance in isolated canine left ventricles demonstrated an inverse linear relationship between pressure and cardiac output when coronary flow was constant.
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