Key result
Deep white matter hyperintensities were associated with depressive symptoms, and this relationship was especially strong in individuals carrying the APOE-4 allele.
Why the study?
Are deep white matter hyperintensities and APOE genotype associated with depressive symptoms in older adults without clinical depression?
Cross-Sectional (n=92)
Are deep white matter hyperintensities and APOE genotype associated with depressive symptoms in older adults without clinical depression?
Cerebrovascular disease, evidenced by deep white matter hyperintensities, may underlie depressive symptoms in older individuals who are not clinically depressed, particularly in APOE-4 carriers.
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Suggests cerebrovascular factors contribute to subsyndromal depression in APOE-4 carriers; hypothesis-generating and warrants longitudinal studies before clinical application.
Nebes et al. (2001) conducted a cross-sectional in Depressive symptoms (n=92). Deep white matter hyperintensities and APOE-4 genotype vs. Periventricular white matter hyperintensities or absence of APOE-4 allele was evaluated on Depressive symptoms assessed by the Geriatric Depression Scale. Deep white matter hyperintensities were associated with depressive symptoms, and this relationship was especially strong in individuals carrying the APOE-4 allele.
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