Key result
Presence and progression of cerebral white matter hyperintensities on MRI were not associated with the development or progression of depressive symptoms in elderly subjects.
Why the study?
Is the presence or progression of cerebral white matter hyperintensities associated with the development of depressive symptoms in elderly subjects at risk of cardiovascular disease?
Population
527 non-demented elderly subjects, aged 70 years or older, at risk of cardiovascular disease
Design
Cohort
Follow-up
33 months (SD 1.6)
Authors
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No association with depressive symptoms does not support MRI white matter assessment for depression risk in elderly cardiovascular patients; leaves open alternative pathways in late-life depression.
Cohort (n=527)
Is the presence or progression of cerebral white matter hyperintensities associated with the development of depressive symptoms in elderly subjects at risk of cardiovascular disease?
In elderly patients at risk for cardiovascular disease, the progression of cerebral white matter lesions on MRI does not appear to be associated with the development of depressive symptoms.
Versluis et al. (2006) conducted a cohort in At risk of cardiovascular disease (n=527). Cerebral white matter hyperintensities vs. Absence or non-progression of white matter hyperintensities was evaluated on Development and progression of depressive symptoms. Presence and progression of cerebral white matter hyperintensities on MRI were not associated with the development or progression of depressive symptoms in elderly subjects.
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