Key result
A nondipper blood pressure pattern in type 2 diabetic patients was associated with increased intima-media thickness (0.77 vs. 0.68; P=0.04) and left ventricular mass index (67 vs. 55; P=0.03).
Why the study?
Are glycemic variability, blood pressure variability, and oxidative stress associated with surrogate measures of cardiovascular outcomes in type 2 diabetic patients?
Population
26 type 2 diabetic patients receiving diet and/or metformin treatment, with no hypotensive treatment or…
Comparison
Assessment of glycemic variability via… vs Dipper vs nondipper blood pressure patterns, and…
Design
Cross-sectional
Authors
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Nondipper pattern signals higher subclinical CV damage in T2D; hypothesis-generating and requires prospective confirmation before guiding care.
Cross-Sectional (n=26)
Are glycemic variability, blood pressure variability, and oxidative stress associated with surrogate measures of cardiovascular outcomes in type 2 diabetic patients?
p-value: p=0.04
Impaired glycemic and blood pressure variability, along with oxidative stress, are associated with early surrogate markers of cardiovascular damage in type 2 diabetic patients with optimal metabolic control.
Flaviani et al. (2011) conducted a cross-sectional in Type 2 diabetes (n=26). Nondipper blood pressure pattern and glycemic variability vs. Dipper blood pressure pattern was evaluated on Intima-media thickness (IMT) (p=0.04). A nondipper blood pressure pattern in type 2 diabetic patients was associated with increased intima-media thickness (0.77 vs. 0.68; P=0.04) and left ventricular mass index (67 vs. 55; P=0.03).
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