Key result
Uncontrolled glycemic variability is linked to increased MACE within 3 months post-PCI.
Why the study?
Glycemic variability may be an independent risk factor for atherosclerotic coronary artery disease and cardiovascular complications after myocardial infarction in diabetic patients.
Does uncontrolled glycemic variability predict major adverse cardiac events in patients undergoing percutaneous coronary intervention?
Observational (n=120)
Does uncontrolled glycemic variability predict major adverse cardiac events in patients undergoing percutaneous coronary intervention?
Uncontrolled glycemic variability is an independent predictor of short-term major adverse cardiac events following percutaneous coronary intervention.
Should not yet change post-PCI care; hypothesis-generating for interventional trials on glycemic variability.
Background: The endothelial dysfunction was greater by glucose fluctuation than by chronic hyperglycemia. The glycemic variability (GV) may be an independent risk factor for atherosclerotic coronary artery disease in diabetic patients. The cardiovascular complications are higher following myocardial infarction in diabetic patients than nondiabetic individuals. Aim of the Work: Our aim is to prove that good controlling of acute shooting of blood glucose level up and down will improve the outcome in patient undergoing percutaneous coronary intervention (PCI). Subjects and Methods: GV is evaluated using intraday variability by fasting, preprandial, and postprandial blood glucose levels in 120 patients. Hemoglobin A1c was used to evaluate glycemic control. The relationship between GV and development of major adverse cardiac events (MACE) in patients undergoing PCI is studied. Results: There is a statistically significant difference between the relation of GV and MACE within 1 month after PCI in uncontrolled diabetes compared to controlled group. There is no statistically significant difference found between the two groups regarding age, gender, risk factors (hypertension, smoking and dyslipidemia), and laboratory parameters including triglycerides, total cholesterol, low-density lipoprotein, and high-density lipoprotein. Conclusions: Uncontrolled GV is associated with poor short-term outcome after PCI in controlled diabetic patients compared to nondiabetic individuals undergoing PCI. Greater GV is associated with composite MACE, especially for uncontrolled diabetic patients. After multivariable logistic analysis, GV remains an independent prognostic factor for composite MACE after 3 months in patients undergoing PCI.
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Eldamanhory et al. (2019) conducted an observational in Percutaneous coronary intervention (n=120). Uncontrolled glycemic variability vs. Controlled glycemic variability was evaluated on Major adverse cardiac events (MACE). Uncontrolled glycemic variability was significantly associated with increased major adverse cardiac events up to 3 months after percutaneous coronary intervention compared to controlled patients.
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