Key result
Ventricular fibrillation resulted in a significant decrease in ventricular electrogram amplitude compared to sinus rhythm, though the two were significantly correlated (R = 0.7, P<0.001).
Why the study?
Does ventricular electrogram amplitude in sinus rhythm predict the amplitude in ventricular fibrillation in patients undergoing defibrillator implantation?
Observational (n=12)
Does ventricular electrogram amplitude in sinus rhythm predict the amplitude in ventricular fibrillation in patients undergoing defibrillator implantation?
Effect estimate: R = 0.7
Absolute Event Rate: 8.3% vs 15.3%
p-value: p=<0.001
Ventricular electrogram amplitude in sinus rhythm correlates with amplitude during ventricular fibrillation, but wide individual variation suggests up to a fourfold decrease can occur during VF.
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Sinus rhythm amplitude may overestimate VF sensing margins due to wide variation; leaves open whether it guides lead placement in defibrillator implantation.
Leitch et al. (1990) conducted an observational in Patients undergoing defibrillator implantation (n=12). Ventricular fibrillation vs. Sinus rhythm was evaluated on Ventricular electrogram amplitude (R = 0.7, p=<0.001). Ventricular fibrillation resulted in a significant decrease in ventricular electrogram amplitude compared to sinus rhythm, though the two were significantly correlated (R = 0.7, P<0.001).
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