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March 2, 2017Biological Chemistry

The role of sirtuins in mitochondrial function and doxorubicin-induced cardiac dysfunction

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Why the study?

Does sirtuin activation mitigate doxorubicin-induced cardiotoxicity without reducing antineoplastic activity?

Population

Patients receiving anthracycline chemotherapy and preclinical models of doxorubicin-induced cardiotoxicity

Design

Review

Authors

VDVernon W. Dolinsky

Discussion

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Overview

Sirtuin activation may protect cardiac mitochondria during doxorubicin therapy; hypothesis-generating for clinical trials.

Structured PICO

Does sirtuin activation mitigate doxorubicin-induced cardiotoxicity without reducing antineoplastic activity?

P
Population
Patients receiving anthracycline chemotherapy (doxorubicin) and preclinical models of doxorubicin-induced cardiotoxicity
I
Intervention
Sirtuin activation (SIRT1 and SIRT3)
O
Outcome
Mitigation of doxorubicin-induced cardiotoxic side-effects

Sirtuin activation represents a potential therapeutic strategy to mitigate doxorubicin-induced cardiotoxicity by preserving mitochondrial function.

Cite This Study

Vernon W. Dolinsky (2017) studied this question.

synapsesocial.com/papers/6a2297cc8bbdc557f5cd3c8fhttps://doi.org/10.1515/hsz-2016-0316
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sirtuin-3 (SIRT3) Protein Attenuates Doxorubicin-induced Oxidative Stress and Improves Mitochondrial Respiration in H9c2 Cardiomyocytes2015 · 173 citations
  2. 2Resveratrol protects against doxorubicin‐induced cardiotoxicity in aged hearts through the SIRT1‐USP7 axis2015 · 111 citations
  3. 3Downregulation of Sirt1 as aging change in advanced heart failure2014 · 114 citations
  4. 4Congestive heart failure in patients treated with doxorubicin2003 · 2,331 citations
  5. 5Fatty Acid Oxidation Enzyme Gene Expression Is Downregulated in the Failing Heart1996 · 679 citations