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Newer diagnostics may streamline poliovirus vaccine standardization; leaves open prospective validation before clinical adoption.
Advancements in the fields of molecular virology, immunology, biochemistry, and physical chemistry have enabled the development of sensitive and specific assays for rapid diagnosis. Similarly, developments in antiviral chemotherapy have provided meaningful incentives. Some of these newly emerging methods have found their way into the laboratories involved in production of poliovirus vaccine, research, and diagnosis. This discussion addresses approaches to standardizing vaccines with these newer techniques.
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Max A. Chemesky (1984) studied this question.
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