Why the study?
Does the smoothness index predict treatment-induced reduction in left ventricular mass index better than the trough:peak ratio in patients with essential hypertension and left ventricular hypertrophy?
Population
174 patients with essential hypertension and left ventricular hypertrophy, aged 20-65 years, enrolled in the…
Comparison
Calculation of the smoothness index for 24 h… vs Calculation of the trough:peak ratio
Design
Cohort
Follow-up
12 months
Authors
Discussion
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Member takes
Implication
The smoothness index is superior to the traditional trough:peak ratio for assessing the homogeneity of 24-hour blood pressure reduction and predicting the regression of left ventricular hypertrophy.
Structured PICO
Does the smoothness index predict treatment-induced reduction in left ventricular mass index better than the trough:peak ratio in patients with essential hypertension and left ventricular hypertrophy?
P
Population
174 patients with essential hypertension and left ventricular hypertrophy, aged 20-65 years, enrolled in the Study on Ambulatory Monitoring of Pressure and Lisinopril Evaluation (SAMPLE)
I
Intervention
Calculation of the smoothness index for 24 h blood pressure reduction following treatment with lisinopril 20 mg (plus 12.5 or 25 mg hydrochlorothiazide as needed)
C
Comparator
Calculation of the trough:peak ratio
O
Outcome
Correlation with treatment-induced reduction in left ventricular mass index (measured by echocardiography)surrogate
The smoothness index is superior to the traditional trough:peak ratio for assessing the homogeneity of 24-hour blood pressure reduction and predicting the regression of left ventricular hypertrophy.
Cite This Study
Parati et al. (1998) studied this question.