Key result
Hyperinsulinemia and regional myocardial ischemia additively increased myocardial glucose uptake by 50% and augmented sarcolemmal GLUT1 and GLUT4 contents by 20% and 60%, respectively (P<0.05).
Why the study?
Does hyperinsulinemia combined with ischemia increase myocardial GLUT1 and GLUT4 translocation in vivo in fasted anesthetized dogs?
Does hyperinsulinemia combined with ischemia increase myocardial GLUT1 and GLUT4 translocation in vivo in fasted anesthetized dogs?
Insulin and ischemia have additive effects to increase in vivo myocardial glucose utilization and augment GLUT1 and GLUT4 translocation.
Does not inform clinical ischemia management; leaves open translation of additive hyperinsulinemia-ischemia effects on myocardial GLUTs from canine models.
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Russell et al. (1998) studied Myocardial ischemia. Hyperinsulinemia and regional myocardial ischemia vs. Saline infusion and nonischemic regions was evaluated on Myocardial glucose uptake and sarcolemmal GLUT1 and GLUT4 content (p=<0.05). Hyperinsulinemia and regional myocardial ischemia additively increased myocardial glucose uptake by 50% and augmented sarcolemmal GLUT1 and GLUT4 contents by 20% and 60%, respectively (P<0.05).
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