Key result
In patients with chronic heart failure, circulating concentrations of BNP/Nt-proBNP correlated closely with BNP mRNA expression in the left ventricle (r = 0.72, P < 0.001).
Population
Patients with severe chronic heart failure undergoing cardiac transplantation, and healthy…
Design
Cross-sectional
Authors
Loading...
May support BNP/Nt-proBNP as LV overload markers in CHF; hypothesis-generating and requires prospective validation before practice change.
Observational
Effect estimate: r = 0.72
p-value: p=< 0.001
Circulating BNP and Nt-proBNP levels closely reflect left ventricular mRNA expression in severe heart failure, supporting their utility as markers of left ventricular overload.
Hystad et al. (2001) conducted an observational in Severe chronic heart failure. Severe chronic heart failure vs. Individuals without known cardiovascular disease and healthy volunteers was evaluated on Correlation between circulating concentrations of BNP/Nt-proBNP and BNP mRNA expression in the left ventricle (r = 0.72, p=< 0.001). In patients with chronic heart failure, circulating concentrations of BNP/Nt-proBNP correlated closely with BNP mRNA expression in the left ventricle (r = 0.72, P < 0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: