Multicomponent Reactions in Organic Synthesis Using Copper‐Based Nanocatalysts

Environment‐friendly and comparatively inexpensive copper‐based nanoparticles have been extensively explored as highly selective catalysts in C−C and C‐heteroatom bond forming reactions. Among them, multicomponent reactions (MCRs), performed with heterogeneous copper‐based nanocatalysts have undergone an explosive growth in recent years. The one pot character of MCRs delivers smaller amount by‐products compared to classical stepwise synthetic routes, with lower costs, time and energy. These advantages of MCRs, along with a variety of readily available cheap copper‐based nanoparticles, enhance the scope to generate many catalytic systems. The present review primarily aims to illustrate the progress of ex situ or in situ generated copper‐based nanoparticles catalyzed various MCRs towards the synthesis of important organic compounds. The mechanistic aspects of the reactions have been highlighted as well.