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August 22, 2018Seminars in Thrombosis and Hemostasis

How to Generate a More Accurate Laboratory-Based International Normalized Ratio: Solutions to Obtaining or Verifying the Mean Normal Prothrombin Time and International Sensitivity Index

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Key result

The provided text is a journal masthead and contains no clinical study data.

Design

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Authors

EFEmmanuel J. FavaloroVascular Medicine

Discussion

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Implication

Transference and EQA strategies may reduce INR variability for VKA patients; leaves open optimal implementation pending prospective validation.

Structured PICO

I
Intervention
Novel strategies to obtain or verify mean normal prothrombin time (MNPT) and international sensitivity index (ISI) values, including transference and use of external quality assessment data
O
Outcome
Accuracy of laboratory-based International Normalized Ratio (INR) valuessurrogate

Implementing transference and external quality assessment strategies can improve the accuracy of MNPT and ISI values, thereby reducing interlaboratory variability in INR results for patients on vitamin K antagonists.

Cite This Study

Emmanuel J. Favaloro (2018) studied this question. The provided text is a journal masthead and contains no clinical study data.

synapsesocial.com/papers/6a229ca3d4af8d4f35118ae2https://doi.org/10.1055/s-0038-1667342
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Standardization of the INR: How Good Is Your Laboratory's INR and Can It Be Improved?2008 · 45 citations
  2. 2Do You Report an Accurate International Normalized Ratio? Find Out Using Local Verification and Calibration2011 · 9 citations
  3. 3Local Verification and Assignment of Mean Normal Prothrombin Time and International Sensitivity Index Values across Various Instruments: Recent Experience and Outcome from North America2013 · 28 citations
  4. 4Comparative Efficacy and Safety of the Non–Vitamin K Antagonist Oral Anticoagulants for Patients with Nonvalvular Atrial Fibrillation2015 · 27 citations
  5. 5Improving the Inter-Laboratory Harmonization of the International Normalized Ratio (INR): Utilizing the Concept of Transference to Estimate and/or Validate International Sensitivity Index (ISI) and Mean Normal Prothrombin Time (MNPT) Values and/or to Eliminate Measurement Bias2012 · 14 citations