Why the study?
Does the choice of thromboplastin reagent affect the consistency of INR values in patients on stable warfarin therapy?
Population
99 patients stabilized on oral anticoagulation (warfarin) across two testing cohorts (n=63 and n=36)
Comparison
INR testing using five different commercially… vs Comparison between different reagents and…
Design
Cross-sectional
Authors
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Thromboplastin choice may introduce INR variability affecting warfarin dosing; leaves open whether low-ISI reagents improve interlaboratory reliability.
Does the choice of thromboplastin reagent affect the consistency of INR values in patients on stable warfarin therapy?
Different thromboplastin reagents can yield clinically significant discrepancies in INR values for patients on warfarin, highlighting the need for standardized low-ISI reagents to improve interlaboratory reliability.
Schmitz et al. (1995) studied this question.
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