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January 1, 1995Journal of Clinical PathologyOpen Access

Effect of thromboplastin and coagulometer interaction on the precision of the International Normalised Ratio.

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Why the study?

How does the interaction between thromboplastin and coagulometer affect the precision of INR values in patients on warfarin?

Population

98 patients on established warfarin treatment

Design

Cross-sectional

Authors

DPD PiJinan UniversityJRJanet RaboudUniversity of TorontoCFCaitlin E. FilbyHudson Institute of Medical Research

Discussion

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Implication

INR supports preference for reporting in warfarin monitoring; leaves open prospective outcome validation in larger cohorts.

Structured PICO

How does the interaction between thromboplastin and coagulometer affect the precision of INR values in patients on warfarin?

P
Population
98 patients on established warfarin treatment
I
Intervention
Four automated phototopical coagulometers used with five commercial thromboplastins (ISI values 0.92-1.97)
O
Outcome
Variability of INR valuessurrogate

Despite interactions between thromboplastin and coagulometers, INR is more precise and preferable to other prothrombin time reporting formats for monitoring warfarin therapy.

Cite This Study

Pi et al. (1995) studied this question.

synapsesocial.com/papers/6a7013fbb27f158178272f1ehttps://doi.org/10.1136/jcp.48.1.13
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reliance on Prothrombin Time Ratios Causes Significant Errors in Anticoagulation Therapy1992 · 93 citations
  2. 2Automation and prothrombin time: a United Kingdom field study of two widely used coagulometers.1990 · 43 citations
  3. 3Failure of the International Normalized Ratio to Generate Consistent Results Within a Local Medical Community1993 · 50 citations
  4. 4Imprecision of Prothrombin Time Monitoring of Oral Anticoagulation: <i>A Survey of Hospital Laboratories</i>1992 · 25 citations
  5. 5Survey of prothrombin time in National External Quality Assessment Scheme exercises (1980-87).1988 · 25 citations