Why the study?
Does the use of thromboplastins with different ISIs result in clinically significant differences in INR values for patients on oral anticoagulants?
Population
1181 frozen plasma samples from patients taking oral anticoagulants for atrial fibrillation
Comparison
Prothrombin time testing and INR determination… vs Pairwise comparisons between different…
Design
Cross-sectional
Authors
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May cause inconsistent dosing decisions across labs; leaves open the need for improved INR standardization.
Does the use of thromboplastins with different ISIs result in clinically significant differences in INR values for patients on oral anticoagulants?
There are clinically significant differences in INRs obtained with different thromboplastins, and low ISI reagents did not perform better, highlighting ongoing challenges in standardizing coagulation testing.
Lind et al. (1999) studied this question.
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