Why the study?
Does the use of thromboplastins with different ISI values affect the validity of INR in expressing prothrombin times in anticoagulated and nonanticoagulated patients?
Population
30 normal plasmas, 30 patients on stable oral anticoagulant therapy, 30 patients with prolonged PTs for…
Comparison
Testing with four thromboplastins with different… vs Comparison across different thromboplastins and…
Design
Other
Authors
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INR may vary by thromboplastin outside stable OA; leaves open standardization needs for non-OA PT reporting.
Does the use of thromboplastins with different ISI values affect the validity of INR in expressing prothrombin times in anticoagulated and nonanticoagulated patients?
INR should not be used to express prothrombin time in patients not on stable oral anticoagulant therapy, as values vary significantly depending on the thromboplastin sensitivity.
Alshameeri et al. (1996) studied this question.