Why the study?
Are commercial thromboplastin ISIs consistent with an International Reference Preparation for calculating INRs in patients on warfarin?
Population
90 patients stabilized on warfarin and 22 normal individuals
Comparison
Five commercial rabbit brain thromboplastins… vs International Reference Preparation
Design
Cross-sectional
Authors
Loading...
May compromise INR reliability for warfarin dosing; leaves open whether local calibration against reference preparations improves accuracy.
Are commercial thromboplastin ISIs consistent with an International Reference Preparation for calculating INRs in patients on warfarin?
The study demonstrates inconsistencies in manufacturers' quoted ISIs for commercial thromboplastins, emphasizing the necessity of reliable plasma calibrants for accurate local INR determination.
Ford et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: