January 2, 2001CirculationOpen Access

Lethal Autoimmune Myocarditis in Interferon-γ Receptor–Deficient Mice

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Population

IFN-gamma receptor-deficient mice (IFN-gammaR) and wild-type mice on a BALB/c background immunized with a…

Comparison

Genetic deletion of IFN-gamma receptor… vs Wild-type mice

Design

Preclinical

Follow-up

3 weeks

Authors

UEUrs ErikssonHeart Failure & Transplant MKMichael KurrerRoswell Park Comprehensive Cancer Center RBRoland BingisserBeiersdorf (Germany)

Discussion

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Implication

IFN-gamma signaling may limit autoimmune myocarditis progression; leaves open therapeutic targeting in human disease.

Structured PICO

Population

IFN-gamma receptor-deficient mice (IFN-gammaR(-/-)) and wild-type mice on a BALB/c background immunized with a peptide derived from cardiac alpha-myosin heavy chain

Intervention

Genetic deletion of IFN-gamma receptor (IFN-gammaR(-/-)) and treatment with nitric oxide synthetase inhibitor N-nitro-l-arginine-methyl-ester

Comparator

Wild-type mice

Outcome

Development of severe myocarditis and mortality

IFN-gamma protects against lethal autoimmune myocarditis by inducing inducible nitric oxide synthase expression and downregulating T-cell responses.

Cite This Study

Eriksson et al. (2001) studied this question.

synapsesocial.com/papers/6a229dfed5ef0a743714abda https://doi.org/10.1161/01.cir.103.1.18

Topics

Myocarditis

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Lethal Autoimmune Myocarditis in Interferon-γ Receptor–Deficient Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Lethal Autoimmune Myocarditis in Interferon-γ Receptor–Deficient Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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