Population
Isolated neonatal rat ventricular myocytes
Design
Preclinical
Authors
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May link IFN-γ to myocyte atrophy in inflammation; hypothesis-generating for proteasome inhibition in human cardiac disease.
IFN-γ induces cardiac myocyte atrophy through selective degradation of myosin heavy chain via proteasome activation, providing a molecular mechanism for cardiac pathology in chronic inflammatory diseases.
Cosper et al. (2012) studied this question.
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