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January 15, 1991Proceedings of the National Academy of SciencesOpen Access

A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor.

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Authors

JRJeffrey S. RubinParadigm Shift Therapeutics (United States)ACAndrew M. ChanChinese University of Hong KongDBDonald P. BottaroNational Cancer Institute

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Implication

Identifies a novel mitogen from lung fibroblasts that stimulates various cell types, indicating its broader biological role.

Key Points

  • The aim was to isolate and characterize a unique mitogen derived from human lung fibroblasts.
  • Isolated mitogen from conditioned medium of human embryonic lung fibroblasts.
  • Conducted purification and sequence analysis to identify its molecular characteristics.
  • Performed recombinant expression in COS-1 cells to confirm identity.
  • Identified a 87 kDa polypeptide as a variant of hepatocyte growth factor.
  • Stimulated rapid tyrosine phosphorylation of a 145-kDa protein in responsive cells.
  • Implicated in the proliferation of melanocytes and endothelial cells.

Cite This Study

Rubin et al. (1991) studied this question.

synapsesocial.com/papers/6a229ea6e4d98b33c2d2b6fdhttps://doi.org/10.1073/pnas.88.2.415
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