Key result
A two-dimensional hexagonal cable model successfully simulated an action potential upstroke velocity of 257 V/s and conduction velocity of 63 cm/s, comparable to experimental results.
A two-dimensional hexagonal spatially discrete cable model accurately reconstructs action potential upstroke velocity and conduction velocity comparable to experimental results from papillary muscles.
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Provides validated framework for cardiac conduction modeling; extends discrete cable approaches but leaves open human translation.
The authors reevaluated the process of action potential propagation in a quantitative manner, using a spacially discrete cable model with an optimized membrane current model. The model reconstructs an action potential upstroke with a higher stroke velocity (V/sub max/) of 451 V/s, which was comparable to that obtained from isolated myocytes (512+or-77 V/s). The gap junctional conductance (G/sub j/) was estimated based upon the conduction velocity (65+or-6 cm/s) along the long axis of papillary muscles. The estimated G/sub j/ was 6 mS/cm/sup 2/, that is 700 nS, which was within the range of the measured gap conductances from paired ventriculocytes. In the one-dimensional model, the V/sub max/ of the simulated propagating action potential was 322 V/s, which was larger than the V/sub max/ obtained from papillary muscles ( theta /sub L/) (237+or-25 V/s) by approximately 35%. In the two-dimensional hexagonal model, the simulated theta /sub L/ was 63 cm/s and the V/sub max/ amounted to 257 V/s, which was comparable to the experimental results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
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Taniguchi et al. (2002) studied this question. Spatially discrete cable model vs. Experimental results from isolated myocytes and papillary muscles was evaluated on Action potential upstroke velocity (V/sub max/) and conduction velocity. A two-dimensional hexagonal cable model successfully simulated an action potential upstroke velocity of 257 V/s and conduction velocity of 63 cm/s, comparable to experimental results.
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