Key result
In a two-dimensional model of cardiac muscle, transverse current flow during longitudinal propagation of an elliptic wave front reduces propagation velocity, Vmax, safety factor, and charging factor.
Population
Two-dimensional model of a thin sheet of cardiac muscle
Design
Preclinical
Authors
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May refine anisotropic conduction models; leaves open experimental validation and clinical relevance.
This computational model demonstrates that action potential characteristics change progressively along an elliptic wave front in cardiac muscle, with transverse current flow providing a drag effect on longitudinal propagation.
Leon et al. (1991) studied Cardiac muscle electrophysiology. Computational model of cardiac muscle was evaluated. In a two-dimensional model of cardiac muscle, transverse current flow during longitudinal propagation of an elliptic wave front reduces propagation velocity, Vmax, safety factor, and charging factor.
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