Key result
Fast action potential upstrokes link to low transverse propagation velocity from recurrent intracellular resistance discontinuities.
Why the study?
The relationship between propagation velocity and action potential upstroke shape in normal cardiac muscle under varying intracellular resistance conditions was unclear.
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Challenges cable theory assumptions in cardiac conduction; leaves open resistive contributions to upstroke morphology for targeted experiments.
Spach et al. (1981) studied Normal canine cardiac muscle propagation. Propagation direction (transverse vs longitudinal to cell axis) was evaluated on Propagation velocity and shape of action potential upstroke. In normal canine cardiac muscle, fast action potential upstrokes were associated with low transverse propagation velocities, indicating recurrent discontinuities in intracellular resistance.
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