Key result
In a one-dimensional fiber model, increasing intercalated disk resistance causes an initial paradoxical increase in Vmax followed by a decrease leading to decremental propagation and conduction block.
Computational modeling highlights the discontinuous nature of cardiac electrical propagation and the role of discrete cellular structure, particularly intercalated disk resistance, in arrhythmogenesis.
No takes yet. Share an insight, caveat, or question.
Intercalated disk resistance may contribute to arrhythmogenesis via paradoxical conduction; extends computational models but leaves open clinical translation.
Rudy et al. (1987) studied Cardiac electrical propagation. Varying intercalated disk resistance and leakage current was evaluated on Electrical propagation characteristics (Vmax, conduction velocity, tau foot). In a one-dimensional fiber model, increasing intercalated disk resistance causes an initial paradoxical increase in Vmax followed by a decrease leading to decremental propagation and conduction block.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: