A model study of the effects of the discrete cellular structure on electrical propagation in cardiac tissue.
Key result
In a one-dimensional fiber model, increasing intercalated disk resistance causes an initial paradoxical increase in Vmax followed by a decrease leading to decremental propagation and conduction block.
Population
One-dimensional fiber model of cardiac muscle containing a periodic intercalated disk structure
Design
Preclinical
Authors
Discussion
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Implication
Intercalated disk resistance may contribute to arrhythmogenesis via paradoxical conduction; extends computational models but leaves open clinical translation.
Structured PICO
P
Population
One-dimensional fiber model of cardiac muscle containing a periodic intercalated disk structure
I
Intervention
Simulation of varying intercalated disk resistance and leakage current to extracellular space
O
Outcome
Macroscopic velocity of propagation, spatial extracellular potential, Vmax, tau foot, and action potential durationsurrogate
Computational modeling highlights the discontinuous nature of cardiac electrical propagation and the role of discrete cellular structure, particularly intercalated disk resistance, in arrhythmogenesis.
Cite This Study
Rudy et al. (1987) studied Cardiac electrical propagation. Varying intercalated disk resistance and leakage current was evaluated on Electrical propagation characteristics (Vmax, conduction velocity, tau foot). In a one-dimensional fiber model, increasing intercalated disk resistance causes an initial paradoxical increase in Vmax followed by a decrease leading to decremental propagation and conduction block.