Key result
A two-dimensional computational model of myocardium demonstrated that transverse connections and structural complexity modulate action potential propagation in agreement with electrophysiological data.
A two-dimensional network model of myocardium successfully simulates transverse propagation and dynamic electrophysiological behavior while reducing computational effort.
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Model insights remain preclinical; leaves open whether transverse connections influence arrhythmia mechanisms in patients.
Leon et al. (1991) studied this question. Two-dimensional computational model was evaluated. A two-dimensional computational model of myocardium demonstrated that transverse connections and structural complexity modulate action potential propagation in agreement with electrophysiological data.
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