Oxidative Damage to DNA and Aging

In Brief VAN REMMEN, H., M. L. HAMILTON, and A. RICHARDSON. Oxidative damage to DNA and aging. Exerc. Sport Sci. Rev., Vol. 31, No. 3, pp. 149–153, 2003. Oxidative damage to DNA increases with age in several tissues and animal models, and mitochondrial DNA has a higher level of oxidative damage than nuclear DNA. Dietary restriction extends lifespan and is associated with reduced levels of damage to mitochondrial and nuclear DNA. The effect of exercise on DNA damage appears to be related to the intensity of the exercise. Oxidative damage to nuclear and mitochondrial DNA is increased with age and ameliorated by the life-extending manipulation, dietary restriction.