Key result
Cognitive tasks of varying complexity and duration altered cerebral blood velocity responses, primarily driven by arterial blood pressure and resistance area product (p<0.002).
Why the study?
Neurovascular coupling assessments with cognitive tasks of varying complexity show similar cerebral blood velocity responses, possibly due to confounding parallel changes in blood pressure and PaCO2.
How do cognitive tasks of varying complexity and duration affect the subcomponents of cerebral blood velocity response in healthy participants?
RCT (n=16)
Randomized paradigms
How do cognitive tasks of varying complexity and duration affect the subcomponents of cerebral blood velocity response in healthy participants?
p-value: p=<0.002
The main contributions to cerebral blood velocity responses during cognitive tasks are neurogenic and myogenic, with a smaller metabolic contribution sensitive to task complexity and duration.
Cognitive tasks modulate cerebral hemodynamics via pressure and resistance in healthy adults; extends neurovascular coupling research but leaves open clinical translation.
A similar pattern of cerebral blood velocity (CBv) response has been observed for neurovascular coupling (NVC) assessment with cognitive tasks of varying complexity and duration. This lack of specificity could result from parallel changes in arterial blood pressure (BP) and PaCO2, which could confound the estimates of NVC integrity. Healthy participants (n = 16) underwent recordings at rest (5 min sitting) and during randomized paradigms of different complexity (naming words (NW) beginning with P-, R-, V- words and serial subtractions (SS) of 100–2, 100–7, 1000–17, with durations of 5, 30 and 60 s). Bilateral CBv (middle cerebral arteries, transcranial Doppler), end-tidal CO2 (EtCO2, capnography), blood pressure (BP, Finapres) and heart rate (HR, ECG) were recorded continuously. The bilateral CBv response to all paradigms was classified under objective criteria to select only responders, then the repeated data were averaged between visits. Bilateral CBv change to tasks was decomposed into the relative contributions (subcomponents) of arterial BP (VBP; neurogenic), critical closing pressure (VCrCP; metabolic) and resistance area product (VRAP; myogenic). A temporal effect was demonstrated in bilateral VBP and VRAP during all tasks (p<0.002), increased VBP early (between 0 and 10 s) and followed by decreases of VRAP late (25–35 s) in the response. VCrCP varied by complexity and duration (p<0.046). The main contributions to CBv responses to cognitive tasks of different complexity and duration were VBP and VRAP, whilst a smaller contribution from VCrCP would suggest sensitivity to metabolic demands. Further studies are needed to assess the influence of different paradigms, ageing and cerebrovascular conditions.
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Ladthavorlaphatt et al. (2022) conducted an RCT in Healthy (n=16). Cognitive paradigms of different complexity and duration (naming words and serial subtractions) vs. Rest was evaluated on Bilateral cerebral blood velocity (CBv) response subcomponents (VBP, VCrCP, VRAP) (p=<0.002). Cognitive tasks of varying complexity and duration altered cerebral blood velocity responses, primarily driven by arterial blood pressure and resistance area product (p<0.002).
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