July 1, 1980Cardiovascular Research
Review: Observations on experimental myocardial ischaemia
Population
Animal models of ischaemia and infarction, and patients with acute myocardial infarction
Design
Review
Authors
Discussion
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Implication
May support timely reperfusion and adjunctive therapies in acute MI; leaves optimal translation from animal models open for trials.
Structured PICO
P
Population
Animal models of ischaemia and infarction, and patients with acute myocardial infarction
I
Intervention
Interventions for salvage of ischaemic myocardium (reperfusion, pharmacological agents, physical and haemodynamic interventions)
O
Outcome
Salvage of ischaemic myocardium
Experimental animal models have clarified the nature of ischaemic cell death and demonstrated that interventions can salvage myocardium in the reversible phase of injury.
Cite This Study
Kloner et al. (1980) studied this question.