Key result
Cx45 and Cx40, but not Cx43, were expressed in the central SA node, with a transitional zone on the endocardial side where Cx43 and Cx45 expression merged at the nodal-crista terminalis border.
Population
Rabbit sinoatrial (SA) node tissue
Design
Preclinical
Authors
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Offers morphological basis for nodal isolation in rabbits; leaves open human translation to conduction or arrhythmia mechanisms.
The distinct spatial compartmentation of connexins in the rabbit SA node provides a morphological basis for its unique electrical coupling properties, restricting hyperpolarizing influence from atrial muscle while allowing impulse exit.
Coppen et al. (1999) studied this question. Connexin expression mapping was evaluated on Spatial pattern of expression of Cx45, Cx40, and Cx43. Cx45 and Cx40, but not Cx43, were expressed in the central SA node, with a transitional zone on the endocardial side where Cx43 and Cx45 expression merged at the nodal-crista terminalis border.
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