Key result
The center of the sinoatrial node expresses Cx45 and Cx30.2 but lacks Cx43 to maintain weak electrical coupling, while the periphery expresses Cx43 and Cx45 to drive atrial muscle.
Differential expression of connexin isoforms, specifically the absence of Cx43 in the center of the SAN and AVN, is essential for protecting pacemaker function and enabling slow conduction.
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Informs SAN pacemaker models; leaves open connexin-targeted therapies for bradyarrhythmias.
Boyett et al. (2006) reported a review. The center of the sinoatrial node expresses Cx45 and Cx30.2 but lacks Cx43 to maintain weak electrical coupling, while the periphery expresses Cx43 and Cx45 to drive atrial muscle.
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