Improved left ventricular diastolic filling in patients with coronary artery disease after percutaneous transluminal coronary angioplasty.
Key result
Percutaneous transluminal coronary angioplasty improved resting left ventricular diastolic filling in CAD patients, increasing peak filling rate from 2.3 to 2.8 EDV/sec (P<0.001).
Why the study?
Does percutaneous transluminal coronary angioplasty improve left ventricular diastolic filling at rest in patients with one-vessel coronary artery disease?
Population
25 patients with one-vessel coronary artery disease, normal resting LV systolic function, and no ECG…
Comparison
Percutaneous transluminal coronary angioplasty vs Baseline (pre-PTCA measurements)
Design
Cohort
Authors
Discussion
Loading...
Member takes
Implication
Supports reversible ischemia-related diastolic dysfunction in single-vessel CAD; leaves open effects on symptoms or outcomes.
Study Design
Type
Observational (n=25)
Structured PICO
Does percutaneous transluminal coronary angioplasty improve left ventricular diastolic filling at rest in patients with one-vessel coronary artery disease?
P
Population
25 patients with one-vessel coronary artery disease, normal resting LV systolic function, and no previous myocardial infarction, evaluated before and after PTCA.
E
Exposure
Percutaneous transluminal coronary angioplasty (PTCA)
C
Comparator
Baseline (pre-PTCA measurements)
O
Outcome
Left ventricular diastolic filling at rest (peak LV filling rate [PFR] and time to PFR)surrogate
Main Result
Absolute Event Rate: 2.8% vs 2.3%
p-value: p=<0.001
Successful PTCA in patients with one-vessel CAD improves resting LV diastolic filling, suggesting these abnormalities are reversible manifestations of impaired coronary flow.
Cite This Study
Bonow et al. (1982) conducted an observational in Coronary artery disease (n=25). Percutaneous transluminal coronary angioplasty (PTCA) vs. Before PTCA (baseline) was evaluated on Peak left ventricular filling rate (PFR) at rest (p=<0.001). Percutaneous transluminal coronary angioplasty improved resting left ventricular diastolic filling in CAD patients, increasing peak filling rate from 2.3 to 2.8 EDV/sec (P<0.001).