Key result
Percutaneous coronary intervention significantly improved LV diastolic parameters at 48 hours, including a decrease in E/e' ratio from 10.03 to 8.62 (P<0.001).
Why the study?
LV diastolic dysfunction often occurs in CAD without systolic dysfunction, and this study investigated whether diastolic function improves after PCI in patients with stable or unstable angina.
Does percutaneous coronary intervention improve left ventricular diastolic function in patients with stable or unstable CAD and normal systolic function?
Population
309 patients with stable or unstable CAD and normal systolic function undergoing successful PCI
Comparison
Before PCI vs 48 h after PCI
Design
Single-center hospital-based study
Follow-up
48 h
Authors
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PCI-linked diastolic gains in CAD without systolic issues support early ischemia marker role; leaves open outcome impact.
Observational (n=309)
No
Does percutaneous coronary intervention improve left ventricular diastolic function in patients with stable or unstable CAD and normal systolic function?
p-value: p=<0.001
Successful percutaneous coronary intervention significantly improves echocardiographic markers of left ventricular diastolic function as early as 48 hours post-procedure in patients with CAD and normal systolic function.
Aggarwal et al. (2021) conducted an observational in Coronary artery disease with normal systolic function (n=309). Percutaneous coronary intervention vs. Baseline (before PCI) was evaluated on Left ventricular diastolic parameters (p=<0.001). Percutaneous coronary intervention significantly improved LV diastolic parameters at 48 hours, including a decrease in E/e' ratio from 10.03 to 8.62 (P<0.001).
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