Key result
A simultaneous cold pressor test did not significantly impact brachial artery exercise-induced flow-mediated dilation compared to control in healthy young men (group × trial interaction P=0.879).
Why the study?
Does a cold pressor test affect brachial artery handgrip exercise-induced flow-mediated dilation in healthy young men?
Does a cold pressor test affect brachial artery handgrip exercise-induced flow-mediated dilation in healthy young men?
Absolute Event Rate: 5.6% vs 6.4%
p-value: p=0.879
A simultaneous sympathoexcitatory painful stimulus (cold pressor test) does not interfere with conduit artery flow-mediated dilation responses during exercise in young healthy men.
Concurrent cold pressor need not alter exercise FMD protocols; confirms intact conduit artery responses despite acute sympathoexcitation in young men.
It is unknown how endothelial-dependent flow-mediated dilation (FMD) stimulated by a sustained, exercise-induced increase in shear stress (EX-FMD) is affected by a simultaneous sympathoexcitatory painful stimulus. The purpose of this study was to examine the impact of a cold pressor test (CPT) on brachial artery EX-FMD elicited by a handgrip exercise-induced increase in shear stress. Participants were healthy males (age 21±2 years) (n=28; 16 Experimental group, 12 Control). Brachial artery diameter and blood velocity were measured using echo and Doppler ultrasound, respectively. Shear stress was estimated by shear rate (shear rate = blood velocity / diameter) and targeted to reach 75 s(-1) in each of two EX-FMD trials in all subjects. In the Experimental group, the second EX-FMD trial was accompanied by simultaneous foot immersion in ice water (simultaneous CPT). The shear rate stimulus did not differ between groups (p=0.823) or trials (p=0.726) (group × trial interaction: p=0.646) (average exercise shear rate (mean ± SD): 67.6±6.2 s(-1)). The CPT (experienced during EX-FMD trial 2 in the Experimental group) increased mean arterial pressure (p<0.001) and heart rate (p=0.002) relative to the Control group. %EX-FMD was not different between groups (p=0.508) or trials (p=0.592) (group × trial interaction: p=0.879) (EX-FMD: Experimental group trial 1: 5.4±3.4%, trial 2: 5.6±2.6%; Control group trial 1: 6.0±3.7%, trial 2: 6.4±2.2%). In conclusion, the CPT did not impact concurrent EX-FMD, and this indicates that an acute painful stimulus does not interfere with conduit artery FMD responses during exercise in young healthy men.
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Stuckless et al. (2015) studied Healthy (n=28). Cold pressor test (foot immersion in ice water) vs. Control (no cold pressor test) was evaluated on Brachial artery exercise-induced flow-mediated dilation (%EX-FMD) (p=0.879). A simultaneous cold pressor test did not significantly impact brachial artery exercise-induced flow-mediated dilation compared to control in healthy young men (group × trial interaction P=0.879).
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